Effects of atropine 0.01% on refractive errors in children with myopia

BackgroundLittle is known about changes in astigmatism during atropine treatment. We aimed to explore the effects of 0.01% eye drops on both spherical and cylindrical refractive errors myopic children.MethodsChildren aged 6–14 years with myopia ≥ −6.00 D < −0.50 D, total > −2.00 at least one were enrolled. Subjects randomised either receive once nightly single-vision lenses or simply wear followed up 3-month intervals. Cycloplegic refraction axial length measured. The magnitude direction (TA), corneal (CA), residual (RA) evaluated.ResultsOverall, 119 eyes (69 group 50 control group) included final analyses after 9 months. Atropine-treated showed significantly less progression than did (spherical equivalent: −0.35 ± 0.33 vs. −0.56 0.49 p = 0.001; length: 0.20 0.19 mm, 0.001). Compared (−0.04 0.23 D), a significant increase TA was observed atropine-treated (−0.14 0.29 D); this mainly attributed CA (−0.17 0.26 D) rather minor decrease RA (0.02 0.32 D).ConclusionsAtropine effective preventing progression, whereas months treatment resulted clinically small, but statistically Chinese children.